In July 2002 he assumed the role of City-Wide Chair and Chief of the Department of Surgery at Western University and served in this role for 14 years. Dr. Denstedt is a Past Chair of the Canadian Association of Surgical Chairs and a past member of the American Urological Association Board of Directors. He completed a 10 year term as Treasurer of the Endourological Society in 2018. 

While maintaining an active clinical practice, Dr. Denstedt is an internationally renowned scholar in urology with career accomplishments encompassing over 250 published papers and book chapters, more than 300 guest professorships in countries throughout the world and numerous honours and awards including being the first Canadian to have won the Gold Cystoscope Award from the American Urological Association in 1998. In 2019 he was awarded the Lifetime Achievement Award from the Endourological Society. Dr. Denstedt has served on the Editorial Board of eight major journals in Urology and is the immediate past Executive Editor of the Journal of Endourology. He is currently the Secretary of the American Urological Association .